Does dysfunctional biological clock increase the risk of Alzheimer's disease?


Disorders in the sleep and wake cycle are a well-known symptom of Alzheimer's disease, but recent studies suggest that an unorganized biological clock can also be a key factor in neurodegenerative disease.

The study of the role of the circadian rhythm in the development of Alzheimer's disease and other forms of dementia is among the many findings to be presented this week at Neuroscience 2018, the annual meeting of the Society for Neuroscience, which takes place at the San Diego Convention Center.

On Monday morning, Brian Lananna, a University of Washington researcher at St. John's University. Louis, presented preliminary findings that show how a click-off on the circadian rhythm on the cellular level can damage the neurons, the brain cells responsible for human understanding.

In Petri dish and mice, researchers have disabled gene cells in astrocytes, star cells that support neurons, and therefore stop producing essential proteins that have caused greater damage to inflammation in drying.

These results require an interesting question: Is the excreted circadian rhythm caused by Alzheimer's disease?

Lananna said probably not. There are many other patterns in the game that a lot of hypotheses involved the formation of other proteins that eventually cause devastating memory loss levels.

However, it is possible, Lananna said that a disturbed biological clock is accelerating the process that is already in progress.

"There are many suggestive evidence, although it is not yet complete that inflammation can be a driving force in Alzheimer's disease," Lananna said. "It is possible that if someone is already developing Alzheimer's, an increase in inflammation with things such as a circadian disorder, a person beyond the edge, or an acceleration of progression."

Further trials will be more accurate at key protein levels in Alzheimer patients, comparing results with those who do not suffer from disease. Over time, an in-depth study could lead to drugs that could be used to compensate if circadian rhythms are not synchronized.

The findings are based on the growing evidence that there are serious consequences for disturbance of circadian rhythms. Other studies have linked the deletion of the biological clock with the range of health effects of heart disease to premature death.

Although this science continues to evolve, researchers are increasingly advising the public that enough sleep, and thus in synchronization with the usual light dark patterns that are present in nature, is likely to have a protective effect.

One important effort in recent years has been limited by the late night time of the screen, which may be shown by some studies, may interfere with normal sleep patterns.

The quality of sleep is another area of ​​further research.

In general, deep sleep proved to be the most useful type of tree, and several documents on Neuroscience 2018 supported this notion.

The Walter Reed Army Institute of Research studied soldiers who were brainwashed and found that this type of trauma was associated with a significant reduction in the amount of deep sleep each participant got each night. The study by Walter Reed pointed out that in the past, soldiers who were in the past for 40 hours of sleep deficiency found out whether their results were at risk or not.

Such a long sleep without sleep, said Cpt. Allison Brager, researcher Walter Reed, was designed to simulate a modern war when many soldiers had to work in the dark, and missions could be extended for more than 24 hours.

"We are really proud of our own night and the consequences that we have in the evening is that you will sleep in peace and that you will move the rhythms of sleep to have dominance," Brager said.

The findings of the study showed that soldiers who had recently had a stroke of the brain after 40 hours of sleep deprivation were slower than about 100 milliseconds from those who were not subjected to coughing. While less than one second, the differences in response times may not seem to be very civil, Brager, who said he was speaking for himself, rather than the US military, said that it could be time to fight crime.

"Under live fire this may be the difference between life or death," Brager said.

The lack of deep sleep also showed that it affects emotional regulation, in line with the findings presented by Eti Ben Simon from the UC Berkeley Sleep Center.

Centers were studied by 18 healthy participants who were evaluated before and after eight hours of evening, where half-sleep and half-sleep were deprived. For those who went without deep sleep, anxiety increased significantly, and brain imaging showed greater activity in the brain that creates emotion, and also in "pre-frontal" areas that usually prevent anxiety.

It seems that a good eight hours of sleep each night is a good anti-anxiety drug.

"If we chronically sleep deprived and have lost sleep, they could feel us more anxiety and the development of anxiety disorder," said Ben Simon.

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