Sunday , March 7 2021

Medicines affect people's personality



In many animal species, individuals exhibit different personalities. For example, some individuals are constantly more bold than others.

"But in biology, we still do not fully understand what people or animals have to show different personalities. People with different levels of signaling substances in the brain, such as serotonin or dopamine, usually behave differently. But we do not know whether differences in these signaling substances can explain differences in personality in other types, and if signaling substances cause noticeable differences or dependence on behavior and levels of signaling substances depends on another basic factor, says Robin Abbey-Lee, postdoctoral at the Department of Physics, Chemistry and biology of IFM, one of the researchers who led the study.

Give people the guts of the medicine
The researchers therefore wanted to actively change the concentration of serotonin and dopamine signaling agents in order to investigate and use the witches for the study. They did this by using drugs that affect serotonin and dopamine systems to treat people with depression or Parkinson's disease. Because the serotonin and dopamine systems of different animals are similar to each other, researchers were expected to have medicines also on worms.

"In this study, we wanted to gain an important knowledge gap by experimenting with the level of these signaling substances and to determine if this could lead to a behavioral change in the cyst," says Hanne Løvlie, IFM, who studied the study.

He then measured the behavior of cricket
The researchers measured three different behavior in cysts.

"We measured how active crickets were in a familiar environment, which corresponds to how much a person moves in his home. We also explored the research behavior of cricket in a new environment, just as a person can behave when visiting a new city. the kruchs behaved in a struggle to measure the aggressiveness of individuals, says Robin Abbey-Lee.

The researchers found that changing the serotonin levels of the gut was less active and less aggressive. Changes in dopamine levels on the other side were not associated with behavioral changes in cyst.

"This shows that serotonin has a clearer primary role in these behaviors," says Hanne Løvlie.

The findings increase our understanding of why animals have a personality. They also raise the question of how medicines that go into nature through our waste water affect wildlife.

Article:
"Experimental manipulation of the level of monoamines changes the personality of the shrimp", Abbey-Lee RN, Uhrig EJ, Garnham L, Lundgren K, Child S, LøvlieH, (2018), Scientific Reports published online on November 1, 2018

Contact person:
Hanne Løvlie, assistant professor, [email protected]
Robin Abbey-Lee, postdoctor, [email protected]


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