Angiotensin converting enzyme inhibitors are a group of medicines used to treat heart failure, high blood pressure (hypertension) or a reduction in complications of a myocardial infarction (heart attack). These drugs are also useful in slowing progression of kidney disease in patients with chronic kidney disease or kidney disease in patients with diabetes. The mechanism of action of angiotensin converting enzyme inhibitors is to reduce the amount of angiotensin II produced. Angiotensin II affects the body to increase blood pressure, blood volume and blood pressure.
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Angiotensin converting enzyme inhibitors dilate the blood vessels by reducing the amount of angiotensin II in the body. They also increase the amount of urine produced by the kidneys. This results in a decrease in blood pressure, a reduction in blood pressure and blood pressure. Due to the inhibition of angiotensin II with angiotensin converting enzyme inhibitors, which helps to reduce blood pressure, the levels of aldosterone and noradrenaline are reduced. Angiotensin converting enzyme inhibitors also inhibit bradykinin, which disseminates blood vessels and thereby reduces blood pressure. These also cause some side effects, depending on the type of angiotensin converting enzyme inhibitors. Side effects include swelling of the face or airway (angioedema), decreased renal function, dizziness, high potassium levels (hyperkalaemia), dry cough and low blood pressure (hypotension).
The increase in the prevalence of high blood pressure is the main factor promoting the market with angiotensin converting enzyme inhibitors. According to the World Health Organization, more than 1 out of 5 adults suffer from high blood pressure worldwide. Complications of high blood pressure cause approximately 9.4 million deaths worldwide every year. An increase in the prevalence of heart failure also promotes the market for angiotensin converting enzyme inhibitors. According to the Center for Disease Control and Prevention (CDC), approximately 5.7 million adults in the US suffer from cardiac failure each year, almost half of these people die within five years of diagnosis.
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The market for global angiotensin converting enzyme inhibitors can be divided by type of disease, dosage form and distribution channel. Depending on the type of disease, the market with angiotensin converting enzyme inhibitors can be converted into cardiac failure, high blood pressure (hypertension), cardiac arrest and kidney disease. Depending on the dosage form, global angiotensin converting enzyme inhibitors may be inhibited into oral tablets and oral solutions. Based on the distribution channel, angiotensin converting enzyme inhibitors can be blocked into online pharmacies, retail pharmacies and hospital pharmacies.
Geographically, the global market for angiotensin converting enzyme inhibitors can be found in Latin America, Asia, Europe, North America and the Middle East, and Africa. North America had the highest market share of angiotensin converting enzyme inhibitors in 2016. Increased prevalence of heart failure, cardiac infarction and high blood pressure leads the market with angiotensin converting enzyme inhibitors in the region. Europe had the second largest market share in 2016. The increase in the prevalence of kidney disease and high blood pressure in the region promotes market growth in the region. It is anticipated that the market for angiotensin-converting enzyme inhibitors in Asia Pacific will encourage an increase in government initiatives for the health sector, especially in countries such as India and China. The global market for angiotensin converting enzyme inhibitors in the Middle East and Africa is targeted at the initiatives taken by governments in the health sector. In Latin America, the market inhibitor of angiotensin converting enzyme is expected to change over the forecast period due to government initiatives for heart disease in the region.
The key players in the worldwide market for angiotensin converting enzyme inhibitors include Bristol-Myers Squibb, a couple of pharmaceutical companies, Inc., UCB, Inc., Pfizer, Inc. and AstraZeneca.