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Specific for tumor cancer therapy


Chinese scientists have developed a combined tumor killer therapy that can be activated specifically at tumor sites in mouse cancer models, which is more effective than previous similar therapies.

The study, published on Science Immunology Friday, described a new immunotherapy for cancer that can prevent the immune system from becoming tolerant of tumors, which occurs in 30 percent of all cancer patients, Xinhua news agency reported.

The team, led by Wang Dangge of the Materia Medica Institute of Science and Technology of the Shanghai Academy of Sciences and Fudan University, developed a common inhibitor of the immune control point in nanoparticle formulation that is very specific to the tumor.

The control point inhibitor is a kind of increasingly popular anti-inflammatory drug. It can block proteins that keep immune T cells from killing cancer. However, a control point inhibitor that is used for target proteins that inhibit the immune system, such as PD-1 and PD-L1, often do not reach deep or metastatic tumors.

Wang's team united nanoparticles carrying anti-PD-L1 antibodies with a light-activated molecule. A molecule called a photosensitizer can produce reactive oxygen species that kill tumors after a tumor-rich study.

In mouse models, local near-infrared radiation that activated the photosensitizer, together with the administration of antibodies-conjugated nanoparticles, promoted the infiltration of T cells that killed cancer cells into the tumor site and tumors became more sensitive to blockage of control points.

This combination also helped nanoparticles effectively inhibit the growth of tumors and metastases on the lungs and lymph nodes, which resulted in approximately 80% survival of the mouse over 70 days compared to total mumps death in 45 days in the group treated with PD antibodies -L1, according to the study.

Posted: July 14, 2019 10:34

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