Friday , March 5 2021

Immunosuppression prevents early delivery



Immunosuppression prevents premature birth Naseem News Quoting Believe The Science We Extend We Immobilize Immunization We Prevent Early Birth Disease, Resistant Immunization Prevents Premature Birth We Expand Our Visitors New News Today With New Winds And We Start With The Most Important News And Inhibition Stops Premature Birth.

Naseem News Early birth is the leading cause of death and disability in the United States, which costs billions of dollars and sorrow each year.

A research report by researchers at the University of Connecticut on reproductive science now shows a potential drug that can stop many premature births and return to normal.

Hospital Hartford Christopher Nolde and immunologist Anthony Villa are interested in the role of the immune system in premature birth.

Usually, most pregnancies take about 40 weeks, so a child born before 37 weeks may be too small to balance body temperature and can not breathe. In some cases, bleeding in the brain or some other organic problems, such as delayed growth and problems of knowledge and perception.

Only in this country, prior to their natural birth, around 337,000 children were born in 2016. For other mammals, early delivery was very rare and usually occurs in the event of infection or inflammation.

The researchers knew cytokines – small proteins that alert the body to infection and cause inflammation – in the amniotic fluid of many premature babies. For this reason, they wonder whether the fetus is completely different from his mother, who must be attacked by the mother's immune system, but during pregnancy it is something to prevent him. What if this protection stopped some women?

"There are many anti-inflammatory mechanisms that prevent the immune disinfection of the fetus, so we thought that serious inflammation could break the safety barrier and begin birth and premature birth," says Villa.

So Nold and Villa took cells from the female genital canal and amniotic fluid surrounding the embryos in the womb, and presented them with the work of bacteria in the laboratory. The result was what they expected when the cells produced a lot of cytokines, as if screaming: "There is gas!"

However, the cytokines were not initially the type of inflammation expected by the researchers, and instead they saw a large part of the factors that promote grazing and granulation colony (GM-CSF). GM-CSF is a type of cytokine that causes rapid growth of cells to become large follicular cells.

Peat concentrations in pregnant women increase rapidly just before birth, but it is not clear whether this is directly related to the birth or side effect of the second procedure.

Discovering Nold and Villa that cytokine (GM-CSF) is released in response to a detected bacterial infection is strange due to the presence of GM-CSF.

Treatment of pregnant mice with this medicine The pre-birth was significantly reduced in mice exposed to dangerous bacterial parts, so the prevention of premature birth will simply, inevitably, change the rules of the game.

Nold and Villa presented a provisional patent for the technique, but researchers must first know whether cytokine (GM-CSF) is the cause of premature birth of women, so Nold collects patterns of some women in early pregnancy to determine if there is anything you can discover early to find out the cause of premature birth.

Nolde and Villa want to test these cytokine samples (GM-CSF) and see if their high levels at the start of pregnancy are evidence of premature termination of pregnancy.

"We hope to do more studies on the immune mechanism in rats, and we hope to study human studies in the near future," said Nold. "Hartford Hospital has already given them little support and are now seeking more funding to continue research.


  • Translation: Kenan Mary
  • Verification: RAND EAAM
  • Editing: زيد أبو الرب

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