Tuesday , March 2 2021

A Covid attack on the brain, not the lungs, triggers severe disease in mice

New York, January 20 (IANS): The researchers found that infection of the muscular nasal passages with the virus that causes Covid-19 caused a rapid, increasing attack on the brain that triggered severe disease, even after the lungs had been successfully cleared of the virus.

According to researchers, including a researcher of Indian origin, the findings affect the understanding of a wide range of symptoms and disease severity in people infected with SARS-CoV-2.

“Our thinking that it’s more about respiratory disease isn’t necessarily true. When it infects the brain, it can affect everything because the brain controls your lungs, heart and everything. The brain is a very sensitive organ. It’s the central processor for everything,” the leader said. researcher Mukesh Kumar, assistant professor at Georgia State University in the US.

A study published in the journal Viruses assessed virus levels in several organs of infected mice. A control group of mice received a dose of sterile saline in the nasal passages.

His team found that the level of the virus in the lungs of infected mice peaked three days after infection and then began to decline.

However, on the fifth and sixth days, very high levels of the infectious virus were found in the brains of all affected mice, at which time symptoms of severe disease, including heavy breathing, disorientation, and weakness, became apparent.

The study showed that the level of the virus in the brain is about 1000 times higher than in other parts of the body.

The researcher said the findings could help explain why some Covid-19 patients appear to be on their way to recovery with improved lung function, but only recur quickly and die.

His research and other studies show that the severity of the disease and the types of symptoms different people have may depend not only on how much virus a person has been exposed to, but on how it has entered their body.

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