The new technique can prevent the infertility of those who have had cancer in children People Entertainment


Washington –

When a person finds out that he has cancer, he may freeze sperm before chemotherapy, which can lead to sterility. But before the puberty children have no sperm to freeze, so they will be 30% infertile due to treatment against this disease.

Researchers have tried to solve this problem for years with the following idea: the elimination of underdeveloped testicular tissue prior to chemotherapy or radiotherapy causes its toxic effects, frozen over the years, and vaccination into the patient's adolescence in the hope of being able to produce normal sperm in puberty.

Three trials performed in monkeys since 2000 have shown that spermatogenesis could work with this type of tissue graft before puberty. But until now, the birth of a child has not occurred.

The team, led by a biologist at the University of Pittsburgh, announced on Thursday that she was able to cross this stage and that a female mack named Grady was born in April 2018 with this technique and in vitro fertilization. Science magazine.

The experiment showed that the credible idea of ​​preserving immature testituclar tissue to help children who had cancer to become parents was credited. For girls, more studies focus on vaccination of the ovaries.

In Pittsburgh, 206 children and 41 cancer-ridden girls have frozen their tissue since 2011, with the hope that this technique will be available for a day, said Kyle Orwig, a professor at the University of Pittsburgh and the lead author of the study.

"I think the technology will be available for clinical use within two to five years," he said, adding that discussions with regulators in the health sector had already taken place.


At the methodological level, AFP highlighted the problem associated with a study led by editors Science consider the possibility of asking for a correction for the authors.

The five macaques in the experiment were chemotherapy, but they were not sterile due to this treatment, Orwig acknowledged.

Monkeys were infertile at the time of vaccination simply because they were castrated, which, according to the authors, is the standard procedure for this type of study.

But although chemotherapy is not mentioned in a study published by Science, Orwig spoke about it in interviews and videos from the university, which may give the wrong impression that the scissors have become sterile due to this treatment. cancer

The AFP study on this difference between the scientific article and its public communication replied that this did not change anything about the success of the experiment, since the sperm used for the birth of Grady came from the grafted tissue.

"I forgot that we decided not to mention the chemotherapy in the study because we thought it was not important for the experiment, and that it did not affect the outcome," said Orwig.

"It's irrelevant" to the result, said Professor Schlatt, the author of the study of science in science. "However, it would be more honest and scientifically correct to mention all the treatments in the manuscript."

In general, scientists report changes in the protocol, albeit minimal, in scientific articles. (I)


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