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Scientists are able to reprogram the cells for the control of infections UNIVERSAL



Scientists from the Pasteur Institute in France have succeeded in reprogramming infection control cells, such as HIV, as published in the journal Nature Metabolism.

Some people have the ability to control HIV naturally without treatment, although one percent of patients can not detect blood propagation after more than 10 years of infection without treatment.

In 2007, scientists at the Pasteur Institute described the exceptional antiviral activity of CD8 lymphocytes in these patients who are capable of rapidly destroying infected CD4 cells.

Scientists continued with their research to identify the specific properties of these cells, so that they could share the same properties for non-control cells.

In this way, scientists have found that CD8 anti-HIV cells in controllers have not only large antiviral potential, but are also programmed for survival, while in uncontrolled cellular programs predisposing them to exhaustion and death cell

Cells of the CD8 controllers use a variety of metabolic sources that are based on the energy provided by their mitochondria, allowing cells to survive under stressful conditions. In contrast, cells other than controllers depend on a single source of energy (glucose) and have limited mitochondrial activity.

In the laboratory, scientists managed to stimulate the action of mitochondria in anti-HIV non-control cells. For this, a substance secreted by the immune system, known as interleukin 15 (IL-15), was used to stimulate the activity of unmanageable mitochondria and increase their anti-HIV potential.

"Our research suggests that even if anti-HIV CD8 cells of uncontroller cells are relatively inefficient compared to those of controllers, we can overcome differences," experts said.


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