An essential nutrient can help fight Alzheimer's disease from generation to generation


Published 09/01/2019 8:08:33CET


In a new study, researchers at the Biodesign Institute at Arizona State University (ASU) have studied safe and simple treatment for one of the most devastating and exciting disorders: Alzheimer's disease. (EA).

Leading authors, Ramón Velázquez and Salvatore Oddo, together with their counterparts at the ASU-Banner Center for the Research of Neurodegenerative Disease (NDRC), are exploring the effects of choline, an important nutrient that could promise a war against memory loss.

The study focuses on mice raised to show symptoms similar to AD. The results showed that when these rodents receive a large amount of cholin in their diet, their descendants show an improvement in spatial memory compared to those who receive a normal cholin scheme in the uterus.

Surprisingly, the beneficial effects of cholin supplements are transgenerational, not only the protection of animals receiving cholin supplementation during pregnancy and breastfeeding, but also the later offspring of these mice.

Although this second generation did not directly receive cholinergic additives, they gained the benefits of treatment, probably due to inherited changes in their genes. Investigation of these epigenetic changes can stimulate new pathways and propose ways to treat a wide range of transgenic problems, including fetal alcohol syndrome and obesity.


Choline works to protect the brain against Alzheimer's disease in at least two ways that have been studied in a new study. First, choline reduces the level of homocysteine, an amino acid that can act as a strong neurotoxin, which contributes to AD characteristics: neurodegeneration and the formation of amyloid plaques.

It is known that homocysteine ​​doubles the risk of developing Alzheimer's disease and is high in patients with Alzheimer's disease. Colin performs chemical transformation and converts harmful homocysteine ​​into useful chemical methionine.

Secondly, supplementation with choline reduces the activation of the microglia, the cells responsible for the disposal of waste in the brain. Although its cleaning functions are essential for brain health, activated microgliders can disappear from control, as is usual during AD. Excessive activation of the microglia causes inflammation of the brain and may eventually lead to neuronal death. Choline supplementation reduces the activation of the microglia, which provides greater protection against the destruction of AD. The findings appear in the current issue of the journal Nature Molecular Psychiatry.


It is now believed that Alzheimer's disease begins to be destroyed in the brain for decades before the onset of clinical symptoms. Once the pathology is diagnosed once, it is always fatal and closes a vital system after another. Mental exacerbation is merciless, as patients have various symptoms that may include confusion, confusion, delusions, lack of memory, aggression, agitation, and progressive loss of motor control.

Choline is a vital nutrient, similar to vitamin that is naturally present in some foods and is also available as a dietary supplement. It is a source of methyl groups that are needed for many steps in metabolism. All plant and animal cells need choline to maintain their structural integrity.

The body uses choline to produce acetylcholine, an important neurotransmitter, which is essential for the functioning of the brain and nervous system, including memory, muscle control and mood. Holin also plays an important role in regulating the expression of genes.

When mice in the study received additional cholin in their diet, their offspring showed significant improvements in spatial memory, which were tested in a water labyrinth. Further examination of the mouse tissue extracted from the hippocampus, a region of the brain, plays a central role in the formation of memory, confirmed the epigenetic changes caused by cholin addition. Modified genes associated with activation of microglia and inflammation of the brain, and reduced levels of homocysteine, have led to the observed improvements in the effectiveness of spatial memory tasks.

Due to chypin-induced epigenetic modifications, improvements were transferred to offspring of mice who received additional cholin in the uterus. The importance of the study is twofold: it identifies the beneficial effects of supplementing nutrients in successive generations and proposes epigenetic mechanisms that explain the reduction in memory deficiency in mice with AD.

Holin is an attractive candidate for the treatment of Alzheimer's disease, as it is a very safe alternative to many pharmaceutical products. The authors conclude that the recommended daily cholin dose is approximately nine times to cause harmful side effects.


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