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Levels of body fat associated with breast cancer in women after menopause



"We have found that overweight body fat in those who have a normal body weight index after menopause is associated with approximately twice the risk of estrogen-dependent breast cancer," said Dr. Andrew Dannenberg, one of the authors of the study and director of cancer prevention at Sandra and the Edward Meyer Cancer Center at Weill Cornell Medicine.
The American Cancer Association says that an estrogen-dependent breast cancer called ER-positive breast cancer in the study appears when the receptor proteins in the cells or on them connect with the hormone estrogen and rely on growth.
The researchers studied 3,460 American women aged 50 to 79 years who survived the menopause. Women were part of the Women's Health Initiative and measured body composition at the beginning of this program, said Dannenberg. Of these women, ER-positive breast cancer has been developed, and researchers have been looking for the relationship between excessive body fat and the development of this cancer.

They found that an increase in body fat of 5 kilograms (11 kilograms) was associated with a 35% increased risk of this type of breast cancer. A 5-kg increase in the fat mass of the trunk was associated with a 56% increase in risk.

Magnesium fat is "determined by the fats contained in the body, with the exception of the head and limbs", according to the study.

The study also showed that for invasive breast cancer, which spread to the surrounding tissue in the breast, the increase in body fat by 5 kilograms was associated with a 28% increase in risk. The same increase in fat fat was associated with a 46% increase in the risk of invasive breast cancer.

"The main incentive is that excessive body fat, even if you have normal body weight, is associated with an increased risk of breast cancer," said Dannenberg.

BMI of a person is calculated according to a formula that includes their height and weight; according to the study, "normal" BMI is between 18.5 and 24.9.

The researchers also studied blood data that were intended for other factors known to be involved in the development of breast cancer, such as raising insulin molecules, at the beginning of the Women's Health Initiative.

The results "emphasize the importance of research that differentiates contributions of body size, body composition and metabolic profiles to the risk of breast cancer", Drs. Isabel Pimentel, Ana Elisa Lohmann and Pamela J. Goodwin published in the editorial paper on the study.

The authors of the editorial board also point out that other researchers looked at the different results with the issue and warned that "these findings indicate that the components of metabolic health and not the presence of a complete metabolic syndrome can contribute to the risk of breast cancer."

How many decades of obesity increase the risk of cancer
The special power of the research for doctor Hodo Anton-Culver, a distinguished professor at the Medical Department at the University of California at Irvine, was the analysis of the location on the body fat level.

"I think this is a good step forward, which leads us to look at the ITM index as an indicator of obesity, which really looks at a particular site of fat concentration in the body," said Anton-Culver, who did not participate in the study.

Scientists knew that there was a link between obesity and cancer, but Anton-Culver says that a new study moves research beyond this general association.

"They say in the summary correctly that obesity is associated with breast cancer, and more precisely, obesity around the abdomen is more specific to this association," she said.

Although Anton-Culver thinks that the study is strong, she pointed out that she found only a certain cancer.

"I do not know if we look at the same problems with other types of cancer, because it's the result, what will it be, or is it specific to breast cancer?" she said. "We need to ask the next question because obesity is a risk factor for other types of cancer."


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