Damage to sperm DNA can be a factor in recurrent spontaneous abortions: a study



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The new study provides the rays of hope for couples affected by recurrent spontaneous abortion, following a study of a new possible cause of a rare and relatively poor condition – sperm anomalies.

For couples who want to expand their family, spontaneous abortion can be a traumatic experience. About one per cent of those who try to have a baby are terrified of repeatedly because of a condition known as a repetitive loss of pregnancy, or RPL.

RPL is historically defined as a sequential loss of at least three pregnancies before the 20th week of pregnancy, although the European Association for Human Reproduction and Embryology last year reduced the number of pregnancy errors to two in the updated guidelines.

When looking for underlying factors, researchers have traditionally focused on women who have been affected by RPL and have isolated a number of health issues that could contribute to a spontaneous cessation of pregnancy. Chromosome defects, uterine malformation, cervical injuries, diabetes and autoimmune disorders have been identified as possible culprits.

However, the cause still remains a mystery. In fact, more than half of the cases are idiopathic, according to the British charity The Miscarriage Association, while the American College of Obstetricians and Gynecologists estimates that between 50% and 75% of cases are unexplained.

Thus, researchers at Imperial College London focused on paternal factors.

"We know that sperm plays an important role in the development of placenta, which is vital for the survival of the unborn child," said Channa Jayasena, lead researcher at the annual Endocrine Society in New Orleans. .

Jayasena and his team were interested in the characteristics of sperm male partners in women who had recurrent spontaneous abortions, in particular the functions of endocrine and metabolic seeds. They employed 50 men whose partner never suffered a loss of pregnancy and 63 men whose partners were affected by the analysis of the seed.

They assessed the level of reproductive hormones, including testosterone, and the number, motility, and morphology of spermatozoa. The researchers also carried out molecular tests to assess levels of oxidative stress in seed material and DNA sperm damage.

Oxidative stress is caused by a compound called reactive oxygen species (ROS). They are usually produced by the body, but in an excessive number they damage the seeds and DNA inserted into the sperm, which affects the fertility of men.

The researchers found that the level of ROS seed, which is four times higher in men affected by RPL, than their partners whose partners were never spontaneously aborted, while the DNA fragmentation rates in the first were twice as high as those in the RPL the latter.

"Male partners in RPL women have reduced serum concentrations of testosterone and serum estrogen compared to controls that require further investigation. We have also reported extreme rates of fragmentation of ROS and sperm DNAs and reduced functional sperm parameters compared to control subjects." study reads.

Spontaneous abortion increases the risk of unsuccessful pregnancies in the future by 14 to 21 per cent after the first loss, 24 to 29 per cent missing after another, and 31 to 33 per cent after the third failed time. And although six out of ten women with RPL continue with year-long pregnancy, estimated unclear reasons for recurrent loss of pregnancy are hindered by targeted therapies for couples who want to become pregnant.

The study is the latest in a recent section that addresses the root causes of RPL outside the female body and examines the possible consequences of a man for this disease. The findings show a new approach to dealing with couples who have experienced repeated spontaneous spontaneous spontaneous spontaneous spontaneous abortions by examining male partners for possible reproductive problems and paving the way for more accurate treatment plans.

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