The test makes it possible to assess whether the patient has produced beneficial antibodies and whether the virus actually stops entering the cells.
January 19, 2021, Tuesday, 14:21
The test results are interpreted as positive or negative according to their value
Lina Laboratory has introduced a new test to detect the activity of protective antibodies against SARS-CoV-2 (COVID-19) after illness or vaccination.
“Antibodies to SARS-CoV-2 virus“ it makes it possible to assess whether the patient has produced beneficial antibodies and whether they actually prevent the virus from entering the cells of the human body. In contrast to the tests available so far, this one offers information on the effective blocking ability of antibodies.
“Antibodies to neutralize the SARS-CoV-2 virus” is not a screening test. It is most suitable for:
- Patients who already have quantified antibodies to COVID-19
- Patients who had COVID-19 for at least 40 days from the onset of the disease
- Patients who have been vaccinated and have had at least 2 weeks of the second dose of
- Desiring to become a convalescent plasma donor who already has quantified antibodies to COVID-19.
How do antibodies block COVID-19?
SARS-CoV-2 contains several structural proteins, the most important being protein proteins (S). It is responsible for binding to ACE2 receptors on the surface of our cells. This recognition and binding takes place through a structure called the receptor binding site (RBD), which is part of the spike protein. As a result, the virus enters the cells, leading to its multiplication and thus to the development of the disease.
SARS-CoV-2 infection triggers an immune response that involves the production of many different antibodies to the protein. They all affect SARS-CoV-2 binding to cells differently, but can only be completely blocked by those directed toward the receptor binding site (RBD).
The newly introduced “neutralizing antibodies against the SARS-CoV-2 virus” detects the presence of precisely these biologically active antibodies that most effectively neutralize the virus’s ability to enter cells. prevent the possibility of infection with COVID – 19.
Where is the test performed and what sample is needed?
Antibodies for neutralization of SARS-CoV-2 virus are carried out in all independent branches of LINA laboratory in the districts: Burgas, Varna, Yambol and Sliven (addresses see here). A blood sample is taken for it. The result comes out in a week. The price of the study is 40 BGN.
The test does not need to be arranged in advance.
What do the results mean?
The test results are interpreted as positive or negative according to their value.
- A score ≥ 20% is considered positive. Positive results indicate the presence of neutralizing antibodies against SARS-CoV-2.
A score of ＜ 20% is considered negative. A negative result may indicate the absence or level below the detection limit of this neutralizing antibody test against SARS-CoV-2. A negative result can also be found in samples taken during acute infection prior to antibody seroconversion.