- New hope for cancer patients
- Soon you can s Antidepressants Colon cancer to treat?
- First promising Experiments with mice
New hope for cancer patients: According to Swiss researchers, the well-known antidepressant “Prozac” can prevent the growth of colon tumors and pancreatic cancer. This is at least proven by the first promising tests in mice.
Prozac against cancer: An antidepressant is supposed to inhibit the growth of cancer
In the current study, a team of researchers from the University of Zurich looked at how serotonin affects cancer cells. Serotonin is also known as the “happiness hormone” and is primarily responsible for our mood. People with low serotonin levels can suffer from depression. Many common antidepressants therefore start here. They are often serotonin reuptake inhibitors and increase serotonin levels in the brain.
However, most serotonin is produced in the intestinal mucosa and stored in platelets. Serotonin reuptake inhibitors (SSRIs) increase serotonin levels in the brain and thus decrease serotonin levels in platelets. As the researchers found, cancer cells use serotonin, which is mediated to disguise itself from immune cells.
How can the antidepressant “fluoxetine,” better known as “prozac,” help against cancer? Because antidepressants lower serotonin in platelets, tumors can no longer use the transfer substance. In experiments on mice, the researchers found that tumor growth in mice slowed significantly and that more T cells moved into cancerous tumors to fight cancer.
Serotonin reuptake inhibitors help identify tumor cells
The study’s researcher explains, “Antidepressants and other serotonin reuptake inhibitors cause immune cells to re-recognize tumor cells and remove them effectively.” In mice, the growth of colon and pancreatic cancer could be slowed.
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“Our results give hope to cancer patients because the drugs used have already been approved for clinical use,” says researcher Pierre-Alain Clavien. It is hoped that the first clinical studies will begin soon.
Also interesting: Antibiotics increase the risk of colon cancer: a study shows a relationship
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