The hormone irisin, which the body secrets in large quantities during exercise, could be useful for treatment against alzheimer, suggests new research published in the journal Nature Medicine.
According to a study carried out by scientists at the Federal University of Rio de Janeiro (Brazil) and the University of Columbia (USA), when the body is carried out, the muscular tissue releases the irisin hormone that enters circulation in the body. and is able to improve the cognitive abilities that have been shown in mice with this disease.
Ottavio Arancio, Sergio Ferreira and research director Fernande de Felice found that the increase in irisin, as well as its predecessor, FNDC5, reduced memory and lack of learning in rodents with Alzheimer's disease.
While they observed that the occurrence of this substance in the brain of diseased mice was blocked, the beneficial cognitive effects of exercise were lost.
According to Efe news agency, scientists explained that, although training is known to improve cognitive abilities and delay progression of neurodegenerative disorders, more research is needed to better understand the functioning of irisin and brain interactions.
They also recognized that more knowledge is needed to assess whether the protein has a similar beneficial cognitive effect in humans.
In any case, they thought that a recent finding could pave the way for new therapeutic strategies that serve to relieve cognitive impairment in patients with Alzheimer's disease, a disease for which no medicine is available.